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Author: Rootman DS, Willoughby RP, Bindlish R, Avaria M, Basu PK, Krajden M
Publication: J Ocul Pharmacol 1992 Winter;8(4):317-23
The Morgan Lens was investigated as a continuous corneal perfusion system in New Zealand white rabbits. Gentamicin concentration in the cornea and aqueous humor delivered by the Morgan Lens was compared to gentamicin drops (13.6 mg/ml) administered every 15 or 30 minutes. Gentamicin (1 mg/ml) or 5 mg/ml was perfused at 10 ml/hr for up to 4.0 hours. At each time interval of 0.5, 1, 2 and 4 hours, homogenized corneas and aqueous humour were assayed for gentamicin concentrations. The highest aqueous humour gentamicin concentrations of 57.99 +/- 12.86 micrograms/ml were significantly higher with the Morgan Lens and 5 mg/ml of gentamicin compared with the Morgan Lens and 1 mg/ml of gentamicin or than drops applied every 30 minutes, but not significantly different than drops every 15 minutes. Highest corneal concentrations of gentamicin of 496.04 +/-101.16 micrograms/gtn cornea were significantly higher with the Morgan Lens and 5 mg/ml of gentamicin compared with the Morgan Lens and 1 mg/ml gentamicin or than drops applied every 30 minutes, but not significantly different than drops every 15 minutes. All mean gentamicin concentrations attained via the MTL exceeded the mean inhibitory concentration for most sensitive bacterial species. The Morgan Lens is a reliable drug delivery system with distinct advantages, and may be a useful therapeutic modality in the ocular delivery of gentamicin and other drugs.
While working at Bethlehem Steel, I had many opportunities to use the Morgan Lens. The employees frequently splashed solutions into their eyes. The Morgan Lens helped us irrigate their eyes promptly and efficiently. We could seat belt the employee/patient into the van, check his eyes, pop in the Morgan Lens, hook up the I.V. bag. While transporting him to the dispensary, his eyes were being irrigated. Prompt irrigation with the Morgan Lens in route to the dispensary helps prevent eye damage.Registered Nurse (Maryland)
The Morgan Lens is used in 90% of hospital emergency departments in the USA and can be inserted in less than 20 seconds. There simply is no other "hands-free" method of eye irrigation. Nothing else frees medical personnel to treat other injuries or to transport the patient while irrigation is underway. Nothing is more effective at treating ocular chemical, thermal, and actinic burns or removing non-embedded foreign bodies, even when the patient's eyes are closed tightly. Its design makes it simple and straightforward to use so minimal training is required.