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Continuous Flow Contact Lens Delivery of Gentamicin to Rabbit Cornea and Aqueous Humor

Author: Rootman DS, Willoughby RP, Bindlish R, Avaria M, Basu PK, Krajden M

Publication: J Ocul Pharmacol 1992 Winter;8(4):317-23

The Morgan Lens was investigated as a continuous corneal perfusion system in New Zealand white rabbits. Gentamicin concentration in the cornea and aqueous humor delivered by the Morgan Lens was compared to gentamicin drops (13.6 mg/ml) administered every 15 or 30 minutes. Gentamicin (1 mg/ml) or 5 mg/ml was perfused at 10 ml/hr for up to 4.0 hours. At each time interval of 0.5, 1, 2 and 4 hours, homogenized corneas and aqueous humour were assayed for gentamicin concentrations. The highest aqueous humour gentamicin concentrations of 57.99 +/- 12.86 micrograms/ml were significantly higher with the Morgan Lens and 5 mg/ml of gentamicin compared with the Morgan Lens and 1 mg/ml of gentamicin or than drops applied every 30 minutes, but not significantly different than drops every 15 minutes. Highest corneal concentrations of gentamicin of 496.04 +/-101.16 micrograms/gtn cornea were significantly higher with the Morgan Lens and 5 mg/ml of gentamicin compared with the Morgan Lens and 1 mg/ml gentamicin or than drops applied every 30 minutes, but not significantly different than drops every 15 minutes. All mean gentamicin concentrations attained via the MTL exceeded the mean inhibitory concentration for most sensitive bacterial species. The Morgan Lens is a reliable drug delivery system with distinct advantages, and may be a useful therapeutic modality in the ocular delivery of gentamicin and other drugs.

While beginning to wear contact lenses, I had an experience which the use of the Morgan Lens saved the day.


I was just finishing a sixteen-hour shift as manager and staff nurse of the ED when I was notified that they had received a bomb threat.  Disaster situation were part of my duties, so I went into action.  By 4:00 AM, I realized I still had my contacts in.  So I got a container and soaked them in an eye solution from our eye tray.  I arrived home with enough time to take a quick nap before returning to work for another sixteen-hour shift.  When I put my contacts in, I felt like someone had placed a hot poker into my eyes.  I took the contacts out, but my eyes continued to burn and were also fire engine red.  I did report to work at 7:00 AM but my eyes continued to burn.  I then decided the best thing I could do was to irrigate, so I placed a Morgan lens into both eyes and irrigated with 1000 cc of lactated Ringer's.  Laying down during the irrigation process was relaxing and I felt no discomfort while my eyes were irrigated.  After the process, the burning was relieved and I was able to complete my shift without further discomfort.

Registered Nurse (South Carolina)

MorTan Inc.

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Why Use The Morgan Lens?

The Morgan Lens is used in 90% of hospital emergency departments in the USA and can be inserted in less than 20 seconds. There simply is no other "hands-free" method of eye irrigation. Nothing else frees medical personnel to treat other injuries or to transport the patient while irrigation is underway. Nothing is more effective at treating ocular chemical, thermal, and actinic burns or removing non-embedded foreign bodies, even when the patient's eyes are closed tightly. Its design makes it simple and straightforward to use so minimal training is required.