Skip to the content

Continuous Flow Contact Lens Delivery of Gentamicin to Rabbit Cornea and Aqueous Humor

Author: Rootman DS, Willoughby RP, Bindlish R, Avaria M, Basu PK, Krajden M

Publication: J Ocul Pharmacol 1992 Winter;8(4):317-23

The Morgan Lens was investigated as a continuous corneal perfusion system in New Zealand white rabbits. Gentamicin concentration in the cornea and aqueous humor delivered by the Morgan Lens was compared to gentamicin drops (13.6 mg/ml) administered every 15 or 30 minutes. Gentamicin (1 mg/ml) or 5 mg/ml was perfused at 10 ml/hr for up to 4.0 hours. At each time interval of 0.5, 1, 2 and 4 hours, homogenized corneas and aqueous humour were assayed for gentamicin concentrations. The highest aqueous humour gentamicin concentrations of 57.99 +/- 12.86 micrograms/ml were significantly higher with the Morgan Lens and 5 mg/ml of gentamicin compared with the Morgan Lens and 1 mg/ml of gentamicin or than drops applied every 30 minutes, but not significantly different than drops every 15 minutes. Highest corneal concentrations of gentamicin of 496.04 +/-101.16 micrograms/gtn cornea were significantly higher with the Morgan Lens and 5 mg/ml of gentamicin compared with the Morgan Lens and 1 mg/ml gentamicin or than drops applied every 30 minutes, but not significantly different than drops every 15 minutes. All mean gentamicin concentrations attained via the MTL exceeded the mean inhibitory concentration for most sensitive bacterial species. The Morgan Lens is a reliable drug delivery system with distinct advantages, and may be a useful therapeutic modality in the ocular delivery of gentamicin and other drugs.

I just spent three hours in the ER.  The trip to the ER was precipitated by my getting a mixture of bleach, Mr. Clean and water in my left eye while scrubbing the soffits of the siding on my house.  Whilst in the ER, I had my eye irrigated twice with a 0.9% solution of NaCl using the Morgan Lens to facilitate the irrigation.  THANK YOU for creating the Morgan Lens.  My eye felt so much better after the second round of irrigation, and it did take two rounds before the pH level in my eye returned to normal.  I know companies always hear about the things that go wrong with their equipment.  I want you to know that your equipment did something wonderful, and I want you to know how very much I appreciate it.

Patient - Platteville, WI

MorTan Inc.

Mailing Address:
P.O. Box 8719
Missoula, MT 59807
U.S.A.

Shipping Address:
329 East Pine St
Missoula, MT 59802
U.S.A.

Toll-Free Telephone1-800-423-8659
Telephone: 406-728-2522
Fax: 
406-728-9332

Emailmortan@morganlens.com

Hours
Monday - Friday
8:00 AM - 4:00 PM MT

Why Use The Morgan Lens?

The Morgan Lens is used in 90% of hospital emergency departments in the USA and can be inserted in less than 20 seconds. There simply is no other "hands-free" method of eye irrigation. Nothing else frees medical personnel to treat other injuries or to transport the patient while irrigation is underway. Nothing is more effective at treating ocular chemical, thermal, and actinic burns or removing non-embedded foreign bodies, even when the patient's eyes are closed tightly. Its design makes it simple and straightforward to use so minimal training is required.