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Continuous Flow Perfusion of Gentamicin with a (Morgan Lens) Reduces Bacterial Colony Counts in Experimental Pseudomonas Keratitis

Author: Rootman DS, Krajden M

Publication: J Ocul Pharmacol 1993 Fall;9(3):271-6

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Abstract: We have previously shown the pharmacokinetic value of delivering gentamicin to the rabbit anterior segment using the Morgan Therapeutic Lens. The present study utilized an intrastromal injection model of Pseudomonas keratitis to test the therapeutic efficacy of continuous flow delivery of gentamicin with the Morgan Lens. All eyes (n = 52) received an intrastromal injection of approximately 1800 colony-forming units (CFU) of Pseudomonas aeruginosa. At 22 hours after injection, eyes were perfused for 6 hours with saline or gentamicin (1, 2.5 or 5 mg/ml), or received gentamicin drops (13.6 mg/ml) at 15 minutes for four doses, then hourly for 6 hours. Corneas were homogenized and plated to determine bacterial survival, and expressed as log colonies (CFU). Log CFU recovered were 7.37 +/- 0.04, 6.64 +/- 0.20, 5.64 +/- 0.31, and 3.56 +/- 0.50 log CFU for saline perfusion, 1, 2.5, 5 mg/ml gentamicin perfusion respectively. Following six hours of treatment with topical fortified gentamicin drops, 5.93 +/- 0.34 log CFU were recovered. Gentamicin perfusion (5 mg/ml) was significantly different from saline or the other treatment groups (P < 0.05). Continuous corneal perfusion with the Morgan Therapeutic Lens demonstrated an increasing dose response curve with increasing perfusate concentration. It was effective in the treatment of experimental Pseudomonas keratitis.

The Oslo University Eye Department has used the Morgan Lens for 16 years.  We use it in all emergency cases and find that it gives the patients better chances than without this equipment.  In fact, we have reduced the need for hospitalization for more than one night for these patients, and the recovery without scars and permanent loss of visions is far better than without it.  Usually, we don't give our recommendations for products like this, but we have been so happy with the Morgan Lens that we would like to recommend it to all ophthalmologists.  Their patients will benefit from its use.

Physician-Ophthalmologist (Norway)

MorTan Inc.

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Why Use The Morgan Lens?

The Morgan Lens is used in 90% of hospital emergency departments in the USA and can be inserted in less than 20 seconds. There simply is no other "hands-free" method of eye irrigation. Nothing else frees medical personnel to treat other injuries or to transport the patient while irrigation is underway. Nothing is more effective at treating ocular chemical, thermal, and actinic burns or removing non-embedded foreign bodies, even when the patient's eyes are closed tightly. Its design makes it simple and straightforward to use so minimal training is required.