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Continuous Flow Perfusion of Gentamicin with a (Morgan Lens) Reduces Bacterial Colony Counts in Experimental Pseudomonas Keratitis

Author: Rootman DS, Krajden M

Publication: J Ocul Pharmacol 1993 Fall;9(3):271-6

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Abstract: We have previously shown the pharmacokinetic value of delivering gentamicin to the rabbit anterior segment using the Morgan Therapeutic Lens. The present study utilized an intrastromal injection model of Pseudomonas keratitis to test the therapeutic efficacy of continuous flow delivery of gentamicin with the Morgan Lens. All eyes (n = 52) received an intrastromal injection of approximately 1800 colony-forming units (CFU) of Pseudomonas aeruginosa. At 22 hours after injection, eyes were perfused for 6 hours with saline or gentamicin (1, 2.5 or 5 mg/ml), or received gentamicin drops (13.6 mg/ml) at 15 minutes for four doses, then hourly for 6 hours. Corneas were homogenized and plated to determine bacterial survival, and expressed as log colonies (CFU). Log CFU recovered were 7.37 +/- 0.04, 6.64 +/- 0.20, 5.64 +/- 0.31, and 3.56 +/- 0.50 log CFU for saline perfusion, 1, 2.5, 5 mg/ml gentamicin perfusion respectively. Following six hours of treatment with topical fortified gentamicin drops, 5.93 +/- 0.34 log CFU were recovered. Gentamicin perfusion (5 mg/ml) was significantly different from saline or the other treatment groups (P < 0.05). Continuous corneal perfusion with the Morgan Therapeutic Lens demonstrated an increasing dose response curve with increasing perfusate concentration. It was effective in the treatment of experimental Pseudomonas keratitis.

The Morgan Lens has proven to be an indispensable aid in my thirteen years of emergency practice.  During that time, my work has taken me to eight or ten different hospitals and medical centers, and I'm always happy to say each and every one of them has kept the Morgan Lens in stock and at the ready.  And, each time a patient is suddenly presented with a chemical or other toxic eye exposure, it is immediately apparent that there is simply no substitute for this product.  In these situations, I have come to depend on it.  I think this testimonial simply reflects what every other emergency physician knows about your landmark device.


...could not effectively irrigate his eyes with IV tubing...

Physician (California)

MorTan Inc.

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Why Use The Morgan Lens?

The Morgan Lens is used in 90% of hospital emergency departments in the USA and can be inserted in less than 20 seconds. There simply is no other "hands-free" method of eye irrigation. Nothing else frees medical personnel to treat other injuries or to transport the patient while irrigation is underway. Nothing is more effective at treating ocular chemical, thermal, and actinic burns or removing non-embedded foreign bodies, even when the patient's eyes are closed tightly. Its design makes it simple and straightforward to use so minimal training is required.